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KMID : 0869619930100040257
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Journal of Korean Society of Hospital Pharmacists
1993 Volume.10 No. 4 p.257 ~ p.266
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Studies on Combined Usage of Combined Preparation of Crude Drugs and Anti-hypertensive Drugs(Ⅰ)
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이석주/Lee, Suk-Joo
김남재/김종우/홍남두/Kim, Nam-Jae/Kim, Jong-Woo/Hong, Nam-Doo
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Abstract
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Effects of Combined usage of combined preparation of crude drugs(Kamichungsimyunja-Tang) and anti-hypertensive drugs were examined in anti-hypertensive effects in rats and diuretic effects in mice. Kamichungsimyunja-Tang is an added and subtracted prescription of Chungsimyunja-Tang which it has become one of the favorate prescriptions at the Oriental Medical Hospital, Kyung-Hee University. Kamichungsimyunja-Tang has been used widely in cardiovascular disorder in Oriental medicines. Kamichungsimyunja-Tang was orally given and anti-hypertensive drugs such as hydralazine, verapamil and atenolol were intravenously given to rats. Effects of combined usage of Kamichungsimyunja-Tang and antihypertensive drugs for the anti-hypertensive actions significantly increased the anti-hypertensive effect of anti-hypertensive drugs. Kamichungsimyunja-Tang and diuretic drugs such as furosemide and hydrochlorothiazide was orally given to mice. Effects of combined usage of Kamichungsimyunja-Tang and diuretic drugs for the diuretic effects significantly increased the effect of diuretic drugs.
These result suggested that combined usage of Kamichungsimyunja-Tang and anti-hypertensive drugs and diuretic drugs for the anti-hypertensive and diuretic actions significantly increased the effect of anti-hypertensive and diuretic drugs.
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